Personal Care
Testing
Comprehensive in-vitro safety and efficacy studies for personal care products using advanced 2D and 3D models. We are committed to promoting cruelty-free practices in the cosmetics and chemical industry through cutting-edge technologies and alternative testing methods.
Ethical Testing Solutions
for Personal Care
We are committed to promoting cruelty-free practices in the cosmetics and chemical industry. Our non-animal testing approach utilizes cutting-edge technologies and alternative testing methods that eliminate the need for animal experimentation, without compromising the accuracy and validity of the results.
By choosing our services, you can have complete confidence that your products have been tested ethically and responsibly.
Key Features
Discover what makes our personal care testing services stand out in the industry.
Cruelty-Free Testing
Promoting cruelty-free practices in the cosmetics and chemical industry with ethical testing methods.
Advanced Technologies
Utilizing cutting-edge technologies and alternative testing methods for superior results.
Accurate Results
Eliminating animal experimentation without compromising accuracy and validity of results.
Ethical Confidence
Complete confidence that your products have been tested ethically and responsibly.
Comprehensive Solutions
From in-vitro studies to clinical trials, we provide end-to-end solutions for your personal care testing needs.
In-vitro Safety and Efficacy Studies
Comprehensive in-vitro safety and efficacy studies using advanced 2D and 3D models for personal care product testing.
Key Offerings:
Advanced Platforms
We are committed to promoting cruelty-free practices in the cosmetics and chemical industry. Our non-animal testing approach utilizes cutting-edge technologies and alternative testing methods that eliminate the need for animal experimentation, without compromising the accuracy and validity of the results.
Advanced Platforms
Cutting-edge cell lines and tissue models for comprehensive testing
HaCaT
Human keratinocyte cell line for skin studies
Human Epidermal Keratinocytes (NHEK)
Primary human epidermal keratinocytes
Human Dermal Fibroblasts (NHDF)
Primary human dermal fibroblasts
Melanocyte cell lines (B16)
Mouse melanoma cell line for pigmentation studies
Keratinocytes and melanocytes (Co-Culture)
Co-culture system for complex skin studies
Human & Mouse Adipocytes
Adipocyte models for skin and body care studies
Induced Pluripotent Stem Cell
iPSC-derived cells for advanced studies
Reconstructed Human tissues
Reconstructed human tissues for advanced studies
Dermal Papillary Organoids
Dermal papillary organoids for advanced studies
Comprehensive Testing Services
Explore our comprehensive testing services across different categories using advanced in-vitro models and cutting-edge technologies.
Skin Irritation & Allergy Studies
Comprehensive skin irritation and allergy studies using advanced in-vitro models to assess the safety and compatibility of personal care products. Our specialized testing protocols ensure thorough evaluation of potential skin reactions.
Skin Irritation - Non irritant
Products can be tested:
Viability of skin cells
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Reconstructed human Epidermis developed using Neonatal and adult cells | SI.VI.RHE.SP.001 | Irritation potential of test compounds against the human tissue models | Spectrophotometry |
| Reconstructed full thickness skin developed using Neonatal and adult cells | SI.VI.RFT.SP.001 | Irritation potential of test compounds against the human tissue models | Spectrophotometry |
Inflammation Studies/Allergy - Non-Allergic
Products can be tested:
Gene expression
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Human epidermal keratinocytes - Neonatal and adult | IS.GE.NKC.QP.001 | mRNA gene expression or protein levels (TNF,IL1A,IL1B,IL6,IL8,IL10,IL17,ICAM,COX2,ALOX5,NFkB,AP1,STAT1,HO-1...) after external induction | qPCR |
| Reconstructed human Epidermis developed using Neonatal and adult cells | IS.GE.RHE.QP.001 | mRNA gene expression or protein levels (TNF,IL1A,IL1B,IL6,IL8,IL10,IL17,ICAM,COX2,ALOX5,NFkB,AP1,STAT1,HO-1...) after external induction | qPCR |
| Reconstructed full thickness skin developed using Neonatal and adult cells | IS.GE.RFT.QP.001 | mRNA gene expression or protein levels (TNF,IL1A,IL1B,IL6,IL8,IL10,IL17,ICAM,COX2,ALOX5,NFkB,AP1,STAT1,HO-1...) after external induction | qPCR |
Protein Synthesis
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Human epidermal keratinocytes - Neonatal and adult | IS.PS.NKC.ELA.001 | mRNA gene expression or protein levels (TNF,IL1A,IL1B,IL6,IL8,IL10,IL17,ICAM,COX2,ALOX5,NFkB,AP1,STAT1,HO-1...) after external induction | ELISA |
| Reconstructed human Epidermis developed using Neonatal and adult cells | IS.PS.RHE.ELA.001 | mRNA gene expression or protein levels (TNF,IL1A,IL1B,IL6,IL8,IL10,IL17,ICAM,COX2,ALOX5,NFkB,AP1,STAT1,HO-1...) after external induction | ELISA |
| Reconstructed full thickness skin developed using Neonatal and adult cells | IS.PS.RFT.ELA.001 | mRNA gene expression or protein levels (TNF,IL1A,IL1B,IL6,IL8,IL10,IL17,ICAM,COX2,ALOX5,NFkB,AP1,STAT1,HO-1...) after external induction | ELISA |
Skincare Testing
Comprehensive skincare testing services covering cytotoxicity, permeation studies, microbiome analysis, sensitization, and phototoxicity assessment using advanced in-vitro models.
Skincare Testing
Advanced skin models for comprehensive safety and efficacy testing
CYTOTOXICITY AND PERMEATION STUDIES
Cytotoxicity - Non-cytotoxic
Products can be tested:
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Human epidermal keratinocytes - Neonatal and adult | CT.VI.NKC.AB.001 | Viability studies after treatment with test compounds | Spectrophotometry |
| Reconstructed human Epidermis developed using Neonatal and adult cells | CT.VI.RHE.AB.001 | Viability studies after treatment with test compounds | Spectrophotometry |
| Reconstructed full thickness skin developed using Neonatal and adult cells | CT.VI.RFT.AB.001 | Viability studies after treatment with test compounds | Spectrophotometry |
Skin Permeation
Products can be tested:
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Reconstructed human Epidermis developed using Neonatal and adult cells | SP.FD.RHE.PC.001 | Permeability coefficient | Franz Cells diffusion |
| Reconstructed full thickness skin developed using Neonatal and adult cells | SP.FD.RFT.PC.001 | Permeability coefficient | Franz Cells diffusion |
MICROBIOME, SENSITIZATION AND PHOTOTOXICITY
Skin Microbiome studies - Microbiome friendly
Products can be tested:
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Reconstructed human Epidermis developed using Neonatal and adult cells | MS.GE.RHE.QP.001 | Good microbes protection to claim microbiome friendly qPCR to identify the pool | qPCR |
| Reconstructed full thickness skin developed using Neonatal and adult cells | MS.GE.RFT.QP.001 | Good microbes protection to claim microbiome friendly qPCR to identify the pool | qPCR |
Phototoxicity studies - Photoprotective
Products can be tested:
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| 3T3 Cells | PS.SF.3T3.AB.001 | Phototoxic potential of a test substance induced by the excited chemical after exposure to light. The test evaluates photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. | Absorbance |
| Human epidermal keratinocytes - Neonatal and adult | PS.SF.NKC.AB.001 | Phototoxic potential of a test substance induced by the excited chemical after exposure to light. The test evaluates photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. | Absorbance |
| Human epidermal Fibroblasts - Neonatal and adult | PS.SF.NFB.AB.001 | Phototoxic potential of a test substance induced by the excited chemical after exposure to light. The test evaluates photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. | Absorbance |
Skin Sensitization
Products can be tested:
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Human epidermal Keratinocytes - Neonatal and adult | SS.SP.NKC.AB.001 | Sensitization potential of test compound | Absorbance |
SKIN PIGMENTATION
Skin Pigmentation - Skin lightening
Products can be tested:
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Human epidermal Melanocytes - Neonatal and adult | SL.SP.NMC.AB.001 | Melanin concentration | Absorbance |
| Human epidermal Keratinocytes - Neonatal and adult | SL.SP.NKC.AB.001 | Melanin concentration | Absorbance |
Skin Pigmentation - Skin lightening
Products can be tested:
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Human epidermal Melanocytes - Neonatal and adult | SL.GE.NMC.QP.001 | Melanogenesis pathways (TYR, TYRP-1, TYRP-2, MITF, and POMC) | qPCR |
| Human epidermal Keratinocytes - Neonatal and adult | SL.GE.NKC.QP.001 | Melanogenesis pathways (TYR, TYRP-1, TYRP-2, MITF, and POMC) | qPCR |
SKIN HYDRATION TEST
Moisturizing and Hydration
Products can be tested:
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Human epidermal keratinocytes | SH.PS.NKC.ELA.001 | Protein (filaggrin, involucrin, cytokeratins, integrin, occludin, claudin, connexins, collagens, desmoglein, B-catenin) or Biomolecules levels (hyaluronic acid, ceramides, GAGs...). | ELISA |
| Reconstructed human Epidermis developed using cells | SH.PS.RHE.ELA.001 | Protein (filaggrin, involucrin, cytokeratins, integrin, occludin, claudin, connexins, collagens, desmoglein, B-catenin) or Biomolecules levels (hyaluronic acid, ceramides, GAGs...). | ELISA |
| Reconstructed full thickness skin developed using cells | SH.PS.RFT.ELA.001 | Protein (filaggrin, involucrin, cytokeratins, integrin, occludin, claudin, connexins, collagens, desmoglein, B-catenin) or Biomolecules levels (hyaluronic acid, ceramides, GAGs...). | ELISA |
Moisturizing and Hydration
Products can be tested:
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Human epidermal keratinocytes - adult and Neonatal and adult and adult | SH.GE.NKC.QP.001 | mRNA expression of genes involved in moisturizing and epidermal barrier pathways (HAS1/2/3, HYAL1/2/3, AQP1/2/3). | qPCR |
| Reconstructed human Epidermis developed using adult and Neonatal and adult and adult cells | SH.GE.RHE.QP.001 | mRNA expression of genes involved in moisturizing and epidermal barrier pathways (HAS1/2/3, HYAL1/2/3, AQP1/2/3). | qPCR |
| Reconstructed full thickness skin developed using adult and Neonatal and adult and adult cells | SH.GE.RFT.QP.001 | mRNA expression of genes involved in moisturizing and epidermal barrier pathways (HAS1/2/3, HYAL1/2/3, AQP1/2/3). | qPCR |
Moisturizing and Hydration
Products can be tested:
| Model | Reference Code | Biomarker Endpoints | Technique |
|---|---|---|---|
| Human epidermal keratinocytes - adult and Neonatal and adult and adult | SH.IF.NKC.IA.001 | Immunofluorescence analysis of biomolecules or proteins using specific antibodies, including DAPI staining for cell nuclei. | Immunofluorescence |
| Reconstructed human Epidermis developed using adult and Neonatal and adult and adult cells | SH.IF.RHE.IA.001 | Immunofluorescence analysis of biomolecules or proteins using specific antibodies, including DAPI staining for cell nuclei. | Immunofluorescence |
| Reconstructed full thickness skin developed using adult and Neonatal and adult and adult cells | SH.IF.RFT.IA.001 | Immunofluorescence analysis of biomolecules or proteins using specific antibodies, including DAPI staining for cell nuclei. | Immunofluorescence |
OTHER KEY STUDIES
Anti-oxidant Potential
Platforms:
Anti-oxidant Potential
Platforms:
Anti-oxidant Potential
Platforms:
Anti-pollution studies
Platforms:
Anti-pollution studies
Platforms:
Anti-pollution studies
Platforms:
Anti-pollution studies
Platforms:
Anti-pollution studies
Platforms:
Anti-Ageing Studies
Platforms:
Anti-Ageing Studies
Platforms:
Anti-Ageing Studies
Platforms:
Anti-Ageing Studies
Platforms:
Anti-Ageing Studies
Platforms:
Anti Acne studies
Platforms:
Clinical Testing
- HRIPT (Dermatologically tested, Clinically tested, Non-irritant, Hypoallergenic and tested under a dermatologist's supervision), 37 days
- Patch Test (Non-irritant and tested under a dermatologist's supervision) 48hrs/72 hrs test
Alternative to Human Clinical Studies
Testing on Reconstructed Human Tissues, which is the functional replica of native human tissues and provides human relevant data similar to the clinical testing.
COMPARISON CHART
| in vitro | 3D Human Tissue | Clinical - Human | |
|---|---|---|---|
| Endpoints (PATCH) | Irritation and Inflammation (quantification) | Irritation, allergy, inflammation and biomarker quantification | Visual inspection for irritation and inflammation |
| Cost | 1-1.5 lakhs | 1.5 - 2.5 lakhs | 25,000 - 2 lakhs |
| Advantage |
|
|
|
| Disadvantage | Basic understanding of product's safety and toxicity | High cost |
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Transform Your
Personal Care Testing
Partner with us to leverage cutting-edge technology and extensive expertise in developing innovative, cruelty-free testing solutions for personal care products.